Molecular, Cellular, and Developmental Biology at the University of Michigan
Molecular, Cellular, and Developmental Biology
Molecular, Cellular, and Developmental Biology

MCDB MCDB MCDB MCDB MCDB MCDB MCDB MCDB MCDB MCDB MCDB MCDB MCDB MCDB MCDB
Linda Barthel of the Raymond Lab.
Members of the Chapman Lab.
Michael O'Connor of the Chapman Lab.
Members of the Jakob Lab.

line
The Department of Molecular, Cellular and Developmental Biology strives to develop new knowledge through basic research about the function of living organisms with focus on the molecular and cellular levels of all branches of life - bacteria, plants, and animals. Our faculty research strengths are animal physiology and neurobiology, biochemistry, cell biology, developmental biology, microbiology and plant molecular biology. We are home to the undergraduate concentration in Cell and Molecular Biology that graduates nearly 200 students per year. Our General Public and Pre-College Students section offers answers to questions about biology. We hope you find our site informative!
line

MCDB News
Undergraduates
and their faculty adviser, Ray Barbehenn, helped explain an observation that had puzzled insect ecologists who study gypsy moth caterpillars. Read more.

MCDB News
Elaina Breznau,
a graduate student in the Miller Lab, was recently awarded a Journal of Cell Science Travelling Fellowship. Read more.

MCDB News
Lilia Popova,
a member of the Schiefelbein Lab, has been selected as a 2013 Intel Science Talent Search Finalist. Read more.

MCDB News
MCDB Professors
James Bardwell, Jianming Li, and Eran Pichersky have been named American Association for the Advancement of Science (AAAS) Fellows. Read more.

MCDB News
Adnan Syed,
a PhD student in the Boles Lab, was recently awarded an American Heart Association Predoctoral Fellowship. Read more.

MCDB News
Professor Emeritus
Sally Allen
passed away November 13, 2012 at age 86 after a brief illness. Sally was professor of biology for over 30 years and was a tireless and dedicated researcher and lecturer. Read more.

Read more MCDB News
border
The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein
PLoS Biol 10(12): e1001440
Xin Xiong, Yan Hao, Kan Sun, Jiaxing Li, Xia Li, Bibhudatta Mishra, Pushpanjali Soppina, Chunlai Wu, Richard I. Hume, Catherine A. Collins

Axonal degeneration is a major problem in neurodegenerative diseases and neuronal injuries, but the process is not well understood. In a paper published in the journal PLOS Biology, University of Michigan graduate student Xin Xiong, together with colleagues in Catherine Collins's lab, report they've identified a protein that functions within neurons to promote the destruction of axons and synapses. It achieves this function by destroying an essential "survival" factor, which is normally transported into axons from the cell body. The protein, named Highwire in Drosophila, is highly conserved from flies to humans, and is previously known for a different role in regulating synapticdevelopment. Data from the study suggest a model in which Highwire promotesaxonal degeneration by destroying the "survival" factor in distal axons. Read this Publication Read All Featured Publications
border

border
MCDB Bottom