Deutsche Bardwell Lab Alumnis

For contact information, click on the names bellow.

Postdoctoral %

Linda Foit
Stefan Gleiter
Ursula Jakob

Doktorand #

Linda Foit
Fabian Himstedt
Stefanie Schmidt
Thomas Zander
Philip Korber
Martin Bader
Hans Buegl

Diplom-Student *

Tobias Baumann
Xaver Kober
Nina Kreissig
Daniel Stephan
Maximillian Kern
Johannes Graumann
Markus Eser
Ulla Grauschopf
Timo Eichner
Jennifer Pfizenmaier
Stephan Hofmann
Philipp Koldewey
Thomas Meier
Isabell Bludau
Alexandra Megner

Praktikant ^

Jan Korner
Julia Hupfeld
Lenz Steimer
Anne Vonhacht
Markus Nees
Jens Schmidt
Katja Eydeler
Jan Riemer
Sebastian Ehm
Stephan Starick
Stefan Jennewei
Tobias Wolfram
Sandra Hauk
Christian Gassner


Olga Mannweiler

Publikationen deutscher Studenten im Labor

Tapley TL, Franzmann TM, Chakraborty S, Jakob U ^, Bardwell JC.
Protein refolding by pH-triggered chaperone binding and release.
Proc Natl Acad Sci U S A. 2010. 107(3):1071-6.

Quan S, Koldewey P ^, Tapley T, Kirsch N, Ruane KM, Pfizenmaier J, Shi R, Hofmann S, Foit L, Ren G, Jakob U, Xu Z, Cygler M, Bardwell JC.
Genetic selection designed to stabilize proteins uncovers a chaperone called Spy.
Antioxid Redox Signal. 2010. 18(3):262-9.

"Foit L ^, Margan GJ, Kern MJ ^, Steimer LR ^, von Hacht AA ^, Titchmarsh J, Warriner SL, Radfor SE, Bardwell JC.
Optimizing protein stability in vivo.
Mol Cell. 2009. 36(5):861-71. Featured by Cell in the Leading Edge and was the subject of a preview in Molecular Cell

Timothy L. Tapley, Jan L. Körner ^, Madhuri T. Barge, Julia Hupfeld ^, Joseph A. Schauerte, Ari Gafni, Ursula Jakob %, and James C. A. Bardwell.
A Functional Role for Protein Disorder: Rapid Activation and Substrate Binding in the Miniature Chaperone HdeA.
PNAS. 2009. In revision.

Linda Foit #, Gareth Morgan, Maximillian Kern ^, Lenz Steimer ^, Anne-Katrin A. von Hacht ^, Stuart L. Warriner, Sheena E. Radford, James C.A. Bardwell.
Protein stabilization by selection. 2009. In Preparation.

Guoping Ren, Daniel Stephan *, Zhaohui Xu, Ying Zheng, Danming Tang, Rosemary S. Harrison, Mareike Kurz, Russell Jarrott, Stephen R. Shouldice, Annie Hiniker, Jennifer L. Martin, Begoña Heras, James C. A. Bardwell.
From reductase to oxidase, the properties of the thioredoxin super family is modulated by a single amino acid residue. 2009. Submitted.

Foit L ^, Mueller-Schickert A, Mamathambika BS, Gleiter S ^, Klaska CL, Ren G, Bardwell JC.
Genetic selection for enhanced folding in vivo targets the Cys14-Cys38 disulfide bond in bovine pancreatic trypsin inhibitor.
Antioxid Redox Signal. 2009. 14(6):973-84.

Gleiter S %, Bardwell JC.
Biochim Biophys Acta. 2008. 1783(4):530-4.

Quan S, Schneider I, Pan J, Von Hacht A ^, Bardwell JC.
The CXXC motif is more than a redox rheostat.
J Biol Chem. 2007. 282(39):38823-33.

Tapley TL, Eichner T, Gleiter S %, Ballou DP, Bardwell JC.
Kinetic characterization of the disulfide bond-forming enzyme DsbB.
J Biol Chem. 2007. 282(14):10263-71.

Goulding CW, Apostol MI, Gleiter S %, Parseghian A, Bardwell J, Gennaro M, and Eisenberg D.
Gram-positive DsbE proteins function differently from gram-negative DsbE homologs: A structure function analysis of DsbE from Mycobacterium tuberculosis.
J. Biol. Chem. 2004. Jan 30;279(5):3516-24. Epub 2003 Nov 3.

Kadokura H., Tian H., Zander T., Bardwell J.C., and Beckwith J.
Snapshots of DsbA in Action: detection of proteins in the process of oxidative folding.
Science. 2004. 303(5657):534-537.

Regeimbal J, Gleiter S %, Trumpower BL, Yu CA, Diwakar M, Ballou DP, Bardwell JC.
Disulfide bond formation involves a quinhydrone-type charge-transfer complex.
Proc Natl Acad Sci U S A. . 2003. Nov 25;100(24):13779-84.

Collet JF, Riemer J ##, Bader MW #, Bardwell JC.
Reconstitution of a disulfide isomerization system.
J Biol Chem. 2002. Jul 26;277(30):26886-92.

Xie T, Yu L, Bader MW #, Bardwell JC, Yu CA.
Identification of the ubiquinone-binding domain in the disulfide catalyst disulfide bond protein B.
J Biol Chem. 2002. Jan 18;277(3):1649-52.

Goldstone D, Haebel PW, Katzen F, Bader MW #, Bardwell JC, Beckwith J, Metcalf P.
DsbC activation by the N-terminal domain of DsbD.
Proc Natl Acad Sci U S A. 2001. Aug 14;98(17):9551-6.

Graumann J *, Lilie H, Tang X, Tucker KA, Hoffmann JH #, Vijayalakshmi J, Saper M, Bardwell JC, Jakob U+.
Activation of the redox-regulated molecular chaperone Hsp33--a two-step mechanism.
Structure (Camb). 2001. May 9;9(5):377-87.

Bader MW #, Hiniker A, Regeimbal J, Goldstone D, Haebel PW, Riemer J##, Metcalf P, Bardwell JC.
Turning a disulfide isomerase into an oxidase: DsbC mutants that imitate DsbA.
EMBO J. 2001. Apr 2;20(7):1555-62.

Bader MW #, Bardwell JC.
Catalysis of disulfide bond formation and isomerization in Escherichia coli.
Adv Protein Chem. 2001. 59:283-301. Review.

Jakob U +, Eser M *, Bardwell JC.
Redox switch of hsp33 has a novel zinc-binding motif.
J Biol Chem. 2000. Dec 8;275(49):38302-10.

Kadokura H, Bader M #, Tian H, Bardwell JC, Beckwith J.
Roles of a conserved arginine residue of DsbB in linking protein disulfide-bond-formation pathway to the respiratory chain of Escherichia coli.
Proc Natl Acad Sci U S A. 2000. Sep 26;97(20):10884-9.

Bugl H #, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U +.
RNA methylation under heat shock control.
Mol Cell. 2000. Aug;6(2):349-60.

Bader MW #, Xie T, Yu CA, Bardwell JC.
Disulfide bonds are generated by quinone reduction.
J Biol Chem. 2000. Aug 25;275(34):26082-8.

Shao F, Bader MW #, Jakob U+, Bardwell JC.
DsbG, a protein disulfide isomerase with chaperone activity.
J Biol Chem. 2000. May 5;275(18):13349-52.

Wong C, Sridhara S, Bardwell JC, Jakob U +.
Heating greatly speeds Coomassie blue staining and destaining.
Biotechniques. 2000. Mar 28;(3):26-8,430,432.

Korber P #, Stahl JM, Nierhaus KH, Bardwell JC.
Hsp15: a ribosome-associated heat shock protein.
EMBO J. 2000. Feb 15;19(4):741-8.

Staker BL, Korber P #, Bardwell JC, Saper MA.
Structure of Hsp15 reveals a novel RNA-binding motif.
EMBO J. 2000. Feb 15;19(4):749-57.

Bader M #, Muse W, Ballou DP, Gassner C, Bardwell JC.
Oxidative protein folding is driven by the electron transport system.
Cell. 1999. Jul 23;98(2):217-27.

Bader M #, Winther JR, Bardwell JC.
Protein oxidation: prime suspect found 'not guilty'.
Nat Cell Biol. 1999. Jul;1(3):E57-8.

Jakob U%, Muse W, Eser M *, Bardwell JC.
Chaperone activity with a redox switch.
Cell . 1999. Feb 5;96(3):341-52.

Korber P #, Zander T #, Herschlag D, Bardwell JC.
A new heat shock protein that binds nucleic acids.
J Biol Chem. 1999. Jan 1;274(1):249-56.

Zander T #, Phadke ND, Bardwell JC.
Disulfide bond catalysts in Escherichia coli.
Methods Enzymol. 1998. 290:59-74.

Guddat LW, Bardwell JC, Glockshuber R, Huber-Wunderlich M, Zander T#, Martin JL.
Structural analysis of three His32 mutants of DsbA: support for an electrostatic role of His32 in DsbA stability.
Protein Sci. 1997. Sep;6(9):1893-900.

Guddat LW, Bardwell JC, Zander T #, Martin JL.
The uncharged surface features surrounding the active site of Escherichia coli DsbA are conserved and are implicated in peptide binding.
Protein Sci. 1997. Jun;6(6):1148-56.

Grauschopf U *, Winther JR, Korber P #, Zander T #, Dallinger P, Bardwell JC.
Why is DsbA such an oxidizing disulfide catalyst?
Cell. 1995. Dec 15;83(6):947-55.

Jakob U #, Meyer I, Bugl H #, Andre S, Bardwell JC, Buchner J.
Structural organization of procaryotic and eucaryotic Hsp90. Influence of divalent cations on structure and function.
J Biol Chem. 1995. Jun 16;270(24):14412-9.