About the Csankovszki Lab
Research in our laboratory encompasses three basic processes relating to developmental biology: regulation of gene expression, segregation of chromosomes, and cytokinesis. While these three processes are seemingly different, our research has uncovered several unexpected and novel connections between them. We found that condensin complexes can contribute to structural changes of chromatin and chromosomes both in the context of gene regulation and in the context of mitotic and meiotic chromosome segregation. Furthermore, we also found that condensin may function away from chromosomes during cytokinesis.
We use the nematode C. elegans
as a model organism to study condensin function. C. elegans
s possesses three distinct condensin complexes, condensin IDC
, condensin I and condensin II (Csankovszki et al. Curr Bio 2009). Condensin IDC
and condensin I differ in only one of five subunits, yet they perform completely different functions. Condensin IDC
regulates expression of genes on the X chromosomes in a process called dosage compensation. By contrast, condensin I, together with condensin II, regulate chromosome segregation during mitosis and meiosis. By dissecting the various contributions of condensin function to each process, our research will provide new insights into how different cellular processes are coordinated to ensure optimal performance of the organism.
Learn more about our research