Abstract Information for NASCE 2013
The deadline for submitting abstracts is 11:59 p.m. EST, February 15, 2013.
There is no abstract fee. However, the corresponding author must register for NASCE 2013 before the abstract can be submitted. The corresponding author will receive a registration number that must be entered in a box on the abstract submission site to complete the abstract submission.
Abstract Submission Rules
- All invited speakers must submit an abstract using the online submission site. Each symposium will have two slots for oral presentations selected from the submitted abstracts. Abstract selection for oral presentation will be done by the NASCE 2013 Program Committee. Abstracts not selected for oral presentation will be programmed for poster presentation. The corresponding author will be notified of the decision.
- There are no restrictions on the number of abstracts you may submit or on the number of accepted abstracts you may present.
- An abstract cannot contain data already accepted for publication as an original manuscript at the time of abstract submission.
- Once submitted, NO REVISIONS to abstracts will be allowed.
- It is the responsibility of the corresponding author to ensure that all coauthors review the abstract prior to submission.
- The presenting or corresponding author on the abstract (or designated substitute) must attend NASCE 2013 to validate the abstract.
- Abstracts should be written in standard scientific format. Use a short, informative title. The abstract should contain a sentence stating the study objective (unless provided in the title), a brief statement of the methods used, a summary of the results obtained and a statement of the conclusions. Use standard abbreviations for units of measure. Non-standard abbreviations should be spelled-out in full at first mention, followed by the abbreviation in parentheses.
- Abstracts are allowed 2,000 characters. Spaces are included in the total character count. The abstract title, authors/institutions, and acknowledgements are NOT counted toward this allotment. The abstract title is limited to 200 characters including spaces.
- Graphics (figures & tables) may not be submitted with abstracts. NASCE 2013 abstracts must be text-only.
- The NASCE 2013 Abstract Submission Site form collects information related to the submission of your abstract.
- Please prepare your abstract file in Microsoft Word or a text editor (accepted formats .docx, .doc, or .rtf). At the bottom of the abstract submission page there is a link that allows you to upload your abstract.
Abstract file should include:
Example abstract format:
- 1. ABSTRACT TITLE - 200 characters maximum including spaces (THE TITLE MUST BE ALL CAPITAL LETTERS)
- 2. Authors (presenting author designated by underline) and affiliations (department, institution, town, state/province, country). Author names should be listed in order of appearance with a number in parentheses after the name that corresponds to the author's department and institution. e.g., Smith, DL (1), Brooks, GD (1)(2), Harvey, PJ (2), Miller, LM (3). (1) Department of Molecular and Cellular Biology, University of Wisconsin, Madison, WI USA (2) Department of Environmental Sciences, University of Wisconsin, Madison, WI USA (3) Department of Biological Sciences, Oklahoma State University, Tulsa, OK USA
- 3. Abstract - 2000 characters maximum including spaces
- 4. Acknowledgements
STRESS HORMONES MODULATE THYROID HORMONE ACTION: SYNERGISTIC TRANSACTIVATION OF THE KRÜPPEL-LIKE FACTOR 9 GENE BY THYROID HORMONE AND CORTICOSTEROID RECEPTORS
Pia Bagamasbad(1) and Robert J. Denver(1)(2)
(1) Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, U.S.A (2) Neuroscience Program, University of Michigan, Ann Arbor, MI, U.S.A.
Synergistic transactivation of target genes by different nuclear receptors (NRs) is an important mechanism for amplifying responses to hormones. A striking example of this occurs during tadpole metamorphosis where glucocorticoid (GC) synergizes with thyroid hormone (TH) to superinduce the expression of TH receptor (TR) target genes, thereby accelerating metamorphosis. The transcription factor Krüppel like factor 9 (Klf9) is a direct TR and corticosteroid receptor (GR/MR) target gene. Klf9 is developmentally regulated in frogs and rodents, and gene expression analysis in frog and mouse cell lines, and in tadpole and rodent brain showed that TH and GC can synergistically induce Klf9 expression. In the current study we investigated the molecular basis for TH and GC synergy on the Klf9 gene. Transient transfection assays with 1 kb fragments of the XenopusKlf9 flanking region identified a sequence between 6 and 5 kb upstream of the transcription start site that supported synergistic Klf9 transactivation. Within this region is an evolutionarily conserved sequence of ~180 bp that we named the Klf9 synergy module. We show that the homologous region of the mouse Klf9 gene also supports hormone synergy. Computer analysis identified several putative NR half sites in the Klf9 synergy module to which TR and GR/MR may bind. We show by electrophoretic mobility shift, DNAseI footprinting and chromatin immunoprecipitation (ChIP) assay that TR and GR bind to specific sequences within the mouse Klf9 synergy module. In addition, we show by ChIP assay that combined treatment of HT22 cells with TH and GC leads to hyperacetylation of histone 4 at the region of the synergy module. These data suggest that hormone-bound TR and GR/MR may cooperate to recruit histone acetyl transferases (HATs) or enhance existing HAT activity. Synergistic transactivation of target genes may be a common mechanism among vertebrates for stress hormones to modulate the developmental actions of TH (supported by NIH grant 1 R01 NS046690 to RJD).
- Abstract Categories. All participants who submit an abstract must choose a general topic area from the Abstract Categories list. If you do not see a relevant topic area for your abstract choose the topic that is nearest to your research. If you feel that your research does not fit within any of the topic areas then choose 'Other'.
- All abstracts submitted for NASCE 2013 will be available for download with the official program from the meeting website. Accepted abstracts will be published in the official journal of the NASCE General and Comparative Endocrinology. The corresponding author will be notified of acceptance of the abstract for NASCE 2013.
- If you need assistance please contact via email: firstname.lastname@example.org.