xu Lab

Publications

(2007- present)

1.Cheng, X., Zhang, X., Gao, Q., Azar, M., Tsang, W.L., Dong, L., Samie, M., Li, X., Zhuo, Y., Garrity, A., Wang, X., Ferrer, M., Dowling, J., Xu, L., Han, R., and Xu, H. (2013) An Intracellular Ca2+ Channel is Required For Sarcolemma Repair to Prevent Muscular Dystrophy. Nature Medicine.  in press.

2. Samie, M., and Xu, H. (2014) Lysosomal exocytosis and lipid storage disorders. Journal of Lipid Research (Invited review).  In press.

3. Sun Y., Yong K., Villa-Diaz, L, Zhang, X., Chen, W., Philson, R., Weng, S., Xu H., Krebsbach,P., and Fu, J (2014). Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells. Nature Materials (2014). In press 

4. Li, X., Wang, X. , Zhang, X. Tsang, W.L, ,Zhao, M., Zhang, Y., Yau R.W., Weisman, LS., and  Xu, H. (2013) A Genetically-encoded Fluorescent probe to visulize intracellualr PI(3,5)P2 localization and dynamics. PNAS (Epub 2013 Dec. 11).  

5. Samie, M., Wang, X. , Zhang, X. ,Goschka, A.,Li, X., Cheng, X., Gregg, E., Azar, M., Zhuo, Y., Garrity, AG,,Gao, Q., Slaugnehaupt, S, Pickel, J., Zolov, S., Weisman, LS., Lenk, G., Titus, S., Bryant-Genevier, M., Southall, N., Juan, M., Ferrer, M., and  Xu, H. (2013) A TRP channel in the lysosome regulates focal exocytosis.  Developmental Cell. Sep 16;26(5):511-24. doi: 10.1016/j.devcel.2013.08.003. Epub 2013 Aug 29.).  

6. Wang W., Zhang, X., Gao, Q., and Xu, H. (2013) TRPML1: an ion channel in the Lysosome. Handbook of Experimental Pharmacology HEP. (in press).

7. Li, X., Garrity A.G, and Xu, H. (2013) Regulation of membrane trafficking by signaling on endosomal and lysosomal membranes. Topical Review. Journal of Physiology. (ePub July 22, 2013).

8. Wang, X. *, Zhang, X. *, Dong, X., Samie, M., Li, X., Cheng, X., Goschka, A., Shen., D.,  Zhou, Y., Harlow, J., Zhu, M.X., Clapham, D.E., Ren, D., and  Xu, H. (2012) TPC Proteins are Sodium-selective Ion Channels in the Endosomes and Lysosomes.  Cell 151, 373-383, Oct. 12, 2012). Evaluated by F1000.

9. Zhang X., Li, X., and Xu, H. (2012) PIP2 Isoforms Determine Compartment-specific Ion Channel Activity . PNAS. 2012 (ePub June 25).

10. Yu, T, Chung C, Shen, D., Xu, H., and Lieberman A.P (2012) Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts . Human Molecular Genetics. 2012 (ePub April 25).

11. Shen, D., Wang, X., Li, X., Zhang, X., Yao, Z, Dibble, S., Dong, X.P, Yu, T, Lieberman A.P, and Xu, H. (2012) Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nature Communications. 2012 Mar 13. 3 : 731 doi: 10.1038/ncomms1735 Evaluated by F1000.

12. Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. (2011) The channel kinase, TRPM7, is required for early embryonic development. PNAS (plus) ePub Dec 27, 2011.

13. Shen, D., Wang, X., and Xu, H. (2011) Pairing Phosphoinositides with Calcium Ions in Endolysosomal Dynamics . BioEssays 2011 Jun;33(6):448-57. doi: 10.1002/bies.201000152. Epub 2011 Apr 28.

14. Dong, XP.*, Shen, D.*, Wang, X.*, Dawson, T., Li, X., Zhang, Q., Cheng, X., Zhang, Y., Weisman, L., Delling, M., and Xu, H. (2010) PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome . Nature Communications, 1:38 doi: 10.1038/ncomms1037 2010 . Evaluated by F1000.

15. Samie, M.A, and Xu, H. (2010) Studying TRP Channels in Intracellualr Membranes. CRC press, Book chapter, TRP Channels--Methods in Signal Transduction Series. Chapter 19. PMID: 22593956 (Pubmed)

16. Cheng, X.*, Jin, J.*, Hu, L., Shen, D., Dong, X., Samie, M.A, Knoff, J., Eisinger, B., Liu, M., Huang, S.M., Caterina, M.J., Dempsey, P., Michael, L.E., Dlugosz, A., Andrews, N., Clapham DE, and Xu H  (2010)  TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation. Cell 2010 10.1016/j.cell.2010.03.013. Leading edge Preview Cell 141, April 16 Featured Publication Science Signaling ec 122 April 20 Evaluated by F1000.

17. Cheng, X., Shen, D., Samie, M.A., and Xu, H. (2010) Mucolipins: Intracellular TRPML1-3 Channels (Invited review). FEBS Letters 2010 Jan. 12 (Epub ahead of print). PDF

18. Mills, E, Dong, X., Wang, F., and Xu, H. (2010) Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders (Invited review). Future Medicinal Chemistry Jan. 2010, Vol. 2, No. 1, Pages 51-64. PDF

19. Dong, X., Wang, X., and Xu, H. (2009) TRP Channels of Intracellular Membranes (Invited review). Journal of Neurochemistry2010 Jan. 28 (Epub ahead of print). PDF

20. Dong, X.*, Wang,X.*, Shen,D.*,Chen, S., Liu, M., Wang, Y., Mills, E.,Cheng, X., Delling, M., and Xu, H. (2009) Activating mutations of the TRPML1 channel revealed by proline scanning mutagenesis.J. Biol. Chem. 10.1074/jbc.M109.037184. PDF

21. Dong, X, Cheng, X., Mills, E., Delling, M., Wang, F., Kurz, T. and Xu, H. (2008) The Type IV Mucolipidosis-Associated Protein TRPML1 is an Endo-lysosomal Iron Release Channel. Nature, 2008 (advance online publication) doi:10.1038/nature07311. PDF Evaluated by F1000.

22. Xu, H. *, Delling, M. *, Li, L*, Dong, X., and Clapham, DE (2007) Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint–waddler mice.Proceedings (USA), 2007, Nov 13;104(46):18321-6. Epub 2007 Nov 7. PDF Evaluated by F1000.

(1998-2006)

1.Xu, H., Delling, M., Jun, JC, and Clapham, DE (2006) Oregano, Thyme, and Clove-derived Flavors and Skin Sensitizers Activate Specific TRP Channels. Nature Neuroscience 2006 May; 9(5):628-635. Epub 2006 Apr 16.PDF

2. Xu, H.*, Blair, NT.*, and Clapham, DE. (2005) Camphor Activates and Strongly Desensitizes TRPV1 in a Vanilloid-independent Mechanism. The Journal of Neuroscience 2005; 25(39): 8924-37. PDF. The work was highlighted in The Journal of Neuroscience, 2005 Sep 28; 25(39), Nature, 2005 Oct 13; 437: 930-931, and Nature Reviews Neuroscience, 2005, 6: 826.

3. Zhuang, ZY., Xu, H., Clapham, DE., and Ji, RR.(2004) Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. The Journal of Neuroscience 2004; 24(38):8300-9. PDF

4. Ito, M.*, Xu, H.*, Guffanti, A., Wei, Y., Zvi, L., Clapham, DE., and Krulwich, TA.(2004) The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis and pH homeostasis of an alkaliphilic Bacillus. Proceedings of the National Academy of Sciences (USA) 2004; 101(29): 10566-71. Epub 2004 Jul 08. PDF

5. Moran, MM., Xu, H, and Clapham, DE. (2004) TRP ion channels in the nervous system. Current Opinion in Neurobiology 2004; 14(3): 362-9. PDF

6. Xu, H.*, Jin, J.*, DeFelice, LJ., Andrews, NC., and Clapham, DE. (2004) A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biology 2004 Mar;2(3):E50. Epub 2004 Mar 16. Synopsis can be found at PLoS Biol. 2004 Mar;2(3):E70. Epub 2004 Mar 16. PDF

7. Koishi, R.*, Xu, H.*, Ren D., Navarro B., Spiller BW., Shi Q., and Clapham, DE. (2004) A superfamily of voltage-gated sodium channels in bacteria. Journal of Biological Chemistry. 279(10):9532-8. Epub 2003 Dec 09. PDF

8. Xu, H.*, Ramsey, IS.*, Kotecha, SA.*, Moran, MM., Chong, JA., Curtis, R., DiStefano, PS., Silos-Santiago, I., Xie, Y., Lawson, D., Ge, P., Lilly, J., and Clapham, DE. (2002). TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature, 418, 181-186, published online 23 June 2002; doi:10.1038/nature00882. PDF Comments about this work and other groups' related articles see "Breakthrough of The Year" by Science, Vol 298, Issue 5602, 2297-2303, 20 December 2002.

9. Ren, D.*, Navarro, B.*, Xu, H.*, Yue, L.*, Shi, Q., and Clapham, DE. (2001). A prokaryotic voltage-gated sodium channel. Science, Dec 14 2001: 2372-2375. Perspectives about this paper can be found in Science, 294: 2306-2308.PDF

10. Wang, R., Rojas, A., Wu, J., Piao, H., Adams C. Y., Xu, H., Shi, Y. and Jiang, C. (2005) Determinant role of membrane helices in gating of intracellular ligand-gated ion channels. Journal of Membrane Biology, 204, 1-10.

11. Wu, J., Xu, H., Shen, W., and Jiang, C. (2004) Expression and coexpression CO2-sensitive Kir channels in brainstem neurons of rats. Journal of Membrane Biology, 197(3):179-91.

12. Cui, N. *, Wu, J. *, Xu, H. *, Wang, R., Rojas, A., Piao, H., Mao, J., Abdulkadir, L., Li, L., and Jiang, C. (2003) A threonine residues (Thr71) plays a critical role in the gating Kir6.2 channel by intracellular ATP and pH. Journal of Membrane Biology, 192, 111-122.

13. Wu, J., Xu, H., Yang, Z., Wang, Y., Mao, J., and Jiang, C (2002). Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures. Journal of Membrane Biology, 190, 105-116.

14. Wu, J., Cui, N., Piao, H., Wang, Y., Xu, H., Mao, J., and Jiang, C. (2002). Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP. Journal of Physiology (London). 543, 495-505.

15. Xu, H., Wu, J., Cui, N., Abdulkadir, L., Wang, R., Mao, J., Giwa, LR., Chanchevalap, S., and Jiang, C. (2001). Distinct histidine residues control the acid-induced activation and inhibition of the cloned KATP channel. Journal of Biological Chemistry, 276, 38690-38696.

16. Jiang, C., Xu, H., Cui, N., and Wu, J. (2001). An alternative approach to the identification of respiratory central chemoreceptors in the brainstem. Respiratory Physiology, 2001 Dec;129(1-2):141-157.

17. Piao, H., Cui, N., Xu, H., Mao, J., Rojas, A., Wang, R., Abdulkadir, L., Li, L., Wu, J., and Jiang, C. (2001). Requirement of multiple protein domains and residues for gating KATP channels by intracellular pH. Journal of Biological Chemistry, 276, 36673-36680.

18. Cui, N., Giwa, LR., Xu, H., Abdulkadir, L., and Jiang, C. (2001). Modulation of the heteromeric Kir4.1-Kir5.1 channels by pCO2 at physiological levels, Journal of Cellular Physiology, 189, 229-236.

19. Jiang, C., Qu, Z., and Xu, H. (2001). Gating of inward rectifier K+ channels by proton-mediated interactions of internal protein domains. Trend in Cardiovascular Medicine, 12, 5-13.

20. Xu, H.*, Cui, N.*, Yang, Z., Wu, J., Giwa, LR., Abdulkadir, L., Sharma, P., and Jiang, C. (2001). Direct activation of KATP channels by intracellular acidosis. Journal of Biological Chemistry, 276, 12898-12902. * Co-first author.

21. Xu, H.*, Yang, Z.*, Cui, N., Valesky, WW., and Jiang, C. (2000). A single residue responsible for the difference of Kir4.1 channel from Kir1.1 in pH-sensitivity, rectification and single channel conductance. Journal of Physiology (London), 528.2, pp. 267-277.

22. Xu, H., Yang, Z., Cui, N., Giwa, LR., Abdulkadir, L., Patel, M., Sharma, P., Shan, G., Shen W., and Jiang C. (2000). Molecular determinants for the distinct pH sensitivity of Kir1.1 and Kir4.1. American Journal of Physiology (Cell) , 279: C1464-C1471.

23. Xu, H., Cui, N., Yang, Z., Qu, Z., and Jiang, C. (2000). Modulation of Kir4.1 and Kir5.1 by hypercapnia and intracellular acidosis. Journal of Physiology (London), 524, 725-735.

24. Yang, Z., Xu, H., Cui, N., Qu, Z., Chanchevalap, S., Shen, W., and Jiang, C. (2000). Biophysical and molecular mechanisms underlying the modulation of heteromeric Kir4.1-Kir5.1 channels by CO2 and pH. Journal of General Physiology 116: 33-46

25. Qu, Z., Yang, Z., Cui, N., Chanchevalap, S., Zhu, G., Liu, C., Xu, H., Shen, W., Wu, J., Li, Y., and Jiang, C. (2000) Kir gating by proton-mediated interactions of N- and C-terminal domains. Journal of Biological Chemistry, 275, 31573-31580.

26. Zhu, G., Liu, C., Chanchevalap, S., Xu, H., and Jiang, C. (2000) CO2 inhibits specific inward rectifier K+ channels by decreases in intra- and extracellular pH. Journal of Cellular Physiology, 183, 53-64.

27. Zhu, G., Zhang, Y., Xu, H. , and Jiang, C. (1998) Characterization of endogenous ionic currents of human embryonic kidney (HEK 293) cells, Journal of Neuroscience Methods. 81(1-2):73-83.

* Co-first author.